Liverpool vs Southampton Betting Prediction, Tips & Preview

September 22, 2025
2 Minute Read

Our Liverpool vs Southampton Prediction Sees Reds Ease Past Championship Side

Liverpool and Southampton square off at Anfield this Tuesday in the third round of the EFL Cup. The Reds are in stunning form, and Arne Slot’s men should ease past the EFL Championship Saints on home soil.

EFL Cup Betting Picks

Liverpool to Win Both Halves – 2.00

Hugo Ekitike to Score Anytime – 1.70

Bet on Liverpool vs Southampton

Liverpool to Secure Seventh Straight Success

Since losing on penalties to Crystal Palace in the FA Community Shield, Liverpool have won every league and cup match. Last weekend’s Merseyside derby victory made it five wins out of five in the Premier League.

Southampton, who were relegated from the top tier last term, have made a disappointing start to their Championship campaign. The Saints languish in 19th place after claiming just one win from their opening six fixtures.

Liverpool are the record winners of this competition, lifting the EFL Cup on ten occasions. Their most recent success came in 2024, when they defeated Chelsea at Wembley Stadium. The Reds are fighting for a lot this season, but Slot’s men are looking to go far in the EFL Cup.

Southampton have never won this competition, though they have reached two finals. In the 2016-17 season, the Saints pushed Manchester United close, eventually falling to a narrow 3-2 defeat at Wembley.

Liverpool vs Southampton Betting Odds

Liverpool are the big favourites in this one, priced at 1.15 to get the job done in normal time. A victory would be their seventh in a row in all competitions.

Will Still’s Southampton are winless since picking up a 3-0 victory at Norwich City in the previous round of the EFL Cup. The visitors are priced at 15.00, while the draw is available at 7.80.

Liverpool Win – 1.15

Draw – 7.60

Southampton Win – 15.00

View Latest Liverpool vs Southampton Odds

Recent Liverpool vs Southampton Head-to-Head Results

Liverpool and Southampton met three times last term, with the Reds winning all three. The Merseyside club have an excellent recent record in this fixture, claiming eight wins and a draw from the past nine meetings.  

Southampton’s last victory over Liverpool came in January 2021. Danny Ings scored after two minutes, and Liverpool failed to recover at St Mary’s. However, that remains the Saints’ only success in this fixture since 2017.

Liverpool vs Southampton Betting Tips & Predictions

This may only be an EFL Cup tie, but Liverpool go into every game looking to win. The home team should be too hot to handle at Anfield, and we like the look of 2.00 for the Reds to win both halves.

Hugo Ekitike has made a strong start to life at Liverpool, scoring four times in nine appearances. Having netted in the Merseyside derby on Saturday, we fancy the Frenchman to score in midweek (1.70).

EFL Cup Betting Picks

Liverpool to Win Both Halves – 2.00

Hugo Ekitike to Score Anytime – 1.70

View Latest EFL Cup Odds

Gareth Hinton

Gareth is an experienced sports betting writer, covering a range of sports. He can write all types of content, ranging from betting tips to in-depth match previews.

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