Manchester United vs Lyon Betting Prediction, Tips & Preview

April 16, 2025
2 Minute Read

Our Manchester United vs Lyon Prediction Sees Red Devils Edge Past French Side

Manchester United and Lyon clash at Old Trafford on Thursday in the second leg of their UEFA Champions League quarter-final. Both sides will fancy their chances of progression after last week’s four-goal draw in France.

Europa League Betting Picks

Manchester United Win & BTTS – 3.20

Joshua Zirkzee to Score Anytime – 2.00

Bet on Man United vs Lyon

Can United Book Place in Last Four?

Man United are having a tough campaign domestically, sitting 14th in the Premier League table with just 38 points to their name. Last weekend, the Red Devils crashed to an embarrassing 4-1 defeat at Newcastle United.

Thankfully for the United faithful, they have been much better in Europe, unbeaten so far. The Manchester giants have won six and drawn five of their 11 Europa League fixtures this season.

Lyon are hunting a UEFA Champions League place in Ligue 1. After 15 wins from 29 games, Olympique sit fourth on 51 points. They warmed up for this crunch European fixture with a 3-1 victory at Auxerre.

The French side have also had a superb Europa League campaign, winning six, drawing four, and losing just one. Can they leave Manchester on Thursday night with a positive result?

Recent Manchester United vs Lyon Head-to-Head Results

The pair played out a 2-2 thriller at the Parc Olympique Lyonnais a week ago. Man United came from behind to lead 2-1 in the dying embers, with Leny Yoro and Joshua Zirkzee on target. However, Rayan Cherki rescued it for Lyon at the death.

They have not met in Manchester since the 2007-08 Champions League knockouts. Cristiano Ronaldo scored the only goal to take United through with a 2-1 aggregate win.

Manchester United vs Lyon Betting Tips & Predictions

Man United have a solid record in this fixture, and the Red Devils should make home advantage count on Thursday. Back the United victory and both teams to score at 3.20.

Zirkzee has had a tough first season at Old Trafford, though the Dutchman scored important Europa League goals against Real Sociedad and Lyon. Zirkzee is priced at 2.00 to net anytime in this one.

Europa League Betting Picks

Manchester United Win & BTTS – 3.20

Joshua Zirkzee to Score Anytime – 2.00

View Latest Europa League Odds

Gareth Hinton

Gareth is an experienced sports writer, specialising in football. He can write all types of content, ranging from blog posts to match previews.

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